Solubilization and purification of a membrane-associated 3,3′,5-tri-iodo-l-thyronine-binding protein from rat erythrocytes
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چکیده
منابع مشابه
Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells.
BACKGROUND Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) have great potential as a cell source for therapeutic applications such as regenerative medicine, disease modeling, drug screening, and toxicity testing. This potential is limited, however, by the immature state of the cardiomyocytes acquired using current protocols. Tri-iodo-l-thyronine (T3) is a growth hor...
متن کاملEvaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity
T(3) (3,5,3'-triiodothyronine) has drawn relatively little attention in relation to cardiovascular (CVS) diseases. The present study was designed to evaluate the cardioprotective action of T(3) in isoproterenol-(ISO-) induced cardiac toxicity. Female Wistar rats were exposed with ISO (100 mg/kg, body weight, subcutaneously) for 2 days at the interval of 24 h followed by T(3) (3 μg/kg, body weig...
متن کاملSolubilization and characterization of a platelet membrane ADP-binding protein.
Previous studies have shown that platelet membranes bind radiolabeled ADP and have nucleoside diphosphokinase activity which transforms added ADP to ATP. In order to further characterize these reactions, the ADP-binding and nucleoside diphosphokinase activity of purified platelet membranes were solubilized by freeze-thaw injury followed by extraction with isotonic buffered saline. Up to 80% of ...
متن کاملJuvenile coho salmon locomotion and mosaic muscle are modified by 3',3',5'-tri-iodo-L-thyronine (T3).
Studies of maximum aerobic swimming performance in smolting juvenile salmonids indicate that these animals may be aerobically compromised during downstream migration. To test our hypothesis that hyperthyroid status contributes to decreased swimming performance through modification of muscle contractility in juvenile (112 mm mean total length) coho salmon (Oncorhynchus kisutch), we measured swim...
متن کاملA case of myxoedema coma successfully treated with tri-iodo-thyronine.
Introduction The termination of myxoedema in coma was described in the Report of the Clinical Society of London(i888) and had been noted even before this (St. Thomas's Hospital Report, I879). It is an uncommon complication occurring in longstanding untreated cases and hitherto was fatal, with the possible exception of one patient (Malden, 1955), and here the cerebro-spinal fluid protein was mar...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1990
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2700577